merck millipore,默克密理愽
  • merck millipore,默克密理博,573109,STAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem

  • merck millipore,默克密理博,573109,STAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem

    产品名称：STAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem
    产品型号：573109
    The STAT3 Inhibitor VIII, 5,15-DPP, also referenced under CAS 22112-89-6, controls the biological activity of STAT3.

    merck millipore,默克密理博,573109,STAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,573109,STAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₃₂H₂₂N₄22112-89-6
    描述
    概述 A cell-permeable porphyrin compound that binds STAT3 (KD = 880 nM by SPR) and prevents STAT3 SH2 domain-mediated ligand binding (IC50 = 280 nM) and dimerization (~60% inhibition at 50 µM in HEK293), while exhibiting much reduced activity against STAT1 ligand binding (IC50 = 10 µM) and no activity againt Grb2 ligand binding even at concentrations as high as 20 µM. One day 5,15-DPP pre-treatment (50 µM) of MDA-MB-468 cultures is shown to greatly inhibit IL-6-induced STAT3, but not STAT1/5a/5b, nuclear translocation (by >90%) and nuclear STAT3 c-myc promoter binding activity, resulting in a more than 90% reduction in cellular c-myc protein level.
    产品目录编号 573109
    品牌系列 Calbiochem®
    同义词 5,15-Diphenylporphyrin
    参考
    参考 Uehara, Y., et al. 2009. Biochem. Biophys. Res. Commun. 380, 627.
    产品信息
    CAS号 22112-89-6
    形式 Off-white solid
    Hill配方 C₃₂H₂₂N₄
    化学配方 C₃₂H₂₂N₄
    Molar Mass 462.5
    结构配方图像
    生物信息
    纯度 ≥90% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,573109,STAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem

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