merck millipore,默克密理博,573095,STAT3 Inhibitor Peptide

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Merck Millipore 默克密理愽

经验配方
C₃₈H₆₃N₈O₁₃P

描述
概述	A Stat3-SH2 domain binding phosphopeptide that acts as a selective inhibitor of Stat3 (signal transducers and activators of transcription 3) signaling with a DB₅₀ of 235 µM (concentration of peptide at which DNA-binding activity is inhibited by 50%). Significantly lowers the DNA-binding activity of Stat3 by forming an inactive Stat3:peptide complex and reduces the levels of active Stat3:Stat3 dimers that can bind DNA. Displays greater affinity for Stat3, and to a lesser extent Stat1, over Stat5.
概述	Supplied as a trifluoroacetate salt.
产品目录编号	573095
品牌系列	Calbiochem®
同义词	Ac-PpYLKTK-OH, STAT3 Inhibitor I

参考
参考	Turkson, J., et al. 2001. J. Biol. Chem. 276, 45443.

产品信息
具有ATP竞争性	N
形式	White lyophilized solid
配方	Supplied as a trifluoroacetate salt.
Hill配方	C₃₈H₆₃N₈O₁₃P
化学配方	C₃₈H₆₃N₈O₁₃P
Molar Mass	870.9
吸湿	Hygroscopic
肽序列	Ac-Pro-Tyr(PO₃H₂)-Leu-Lys-Thr-Lys-OH
可逆	N

生物信息
主靶	STAT3
纯度	≥95% by HPLC

理化信息
细胞可渗透	N
溶解度	H₂O
肽序列	Ac-Pro-Tyr(PO₃H₂)-Leu-Lys-Thr-Lys-OH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,573095,STAT3 Inhibitor Peptide

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