merck millipore,默克密理愽
  • merck millipore,默克密理博,HTS193RTA,Ready-to-Assay™ S1P5 Lysophospholipid Receptor Frozen Cells

  • merck millipore,默克密理博,HTS193RTA,Ready-to-Assay™ S1P5 Lysophospholipid Receptor Frozen Cells

    产品名称：Ready-to-Assay™ S1P5 Lysophospholipid Receptor Frozen Cells
    产品型号：HTS193RTA
    Human S1P5 / EDG8 GPCR frozen cells for Calcium Flux FLIPR Assays.

    merck millipore,默克密理博,HTS193RTA,Ready-to-Assay™ S1P5 Lysophospholipid Receptor Frozen Cells

  • 产品介绍
  • merck millipore,默克密理博,HTS193RTA,Ready-to-Assay™ S1P5 Lysophospholipid Receptor Frozen Cells

    重要规格表

    应用说明 品种 宿主细胞 蛋白靶
    Calcium Flux AssaysHumanChem-5S1P5 / EDG8
    描述
    产品目录编号 HTS193RTA
    商名
    • Ready-to-Assay
    描述 Ready-to-Assay™ S1P5 Lysophospholipid Receptor Frozen Cells
    背景信息 Millipore’s Ready-to-Assay GPCR frozen cells are designed for simple, rapid calcium assays with no requirement for intensive cell culturing. Millipore has optimized the freezing conditions to provide cells with high viability and functionality post-thaw. The user simply thaws the cells and resuspends them in media, dispenses cell suspension into assay plates and, following over night recovery, assays for calcium response.

    Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that transmits signals through a family of five G-protein-coupled receptors to regulate cell proliferation, migration, cytoskeletal organization, and differentiation (Spiegel and Milstien 2003). S1P5 can couple with Gi/o and G12/13, and it mediates S1P induced adenylate cyclase inhibition and Ca2+ mobilization like the other S1P receptors. However, unlike the other S1P receptors, it mediates inhibition of MAPK activation and cell proliferation (Im et al., 2000). S1P5 is predominantly expressed in the white matter tracts and oligodendrocytes and is particularly abundant in the anterior commissure, corpus collosum, and optic tract (Terai et al., 2003). S1P induces process retraction in pre-oligodendrocytes and supports cell survival in mature oligodendrocytes by activating S1P5, which indicates a role for S1P5 in maturation and myelination of oligodendrocytes (Jaillard et al., 2005). Millipore’s cloned human S1P5-expressing cell line is made in the Chem-5 host, which supports high levels of recombinant S1P5 expression on the cell surface and contains optimized levels of a recombinant promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists, antagonists and modulators at S1P5 Receptor.
    产品信息
    部件
    • Fifty (50) mL of Media Component.
    • Pack contains 2 vials of mycoplasma-free cells, 1 ml per vial.
    检测方法 Fluorescent
    应用
    应用 Human S1P5 / EDG8 GPCR frozen cells for Calcium Flux FLIPR Assays.
    应用说明 Calcium Flux Assays
    生物信息
    品种 Human
    Entrez基因编号
    • NM_030760
    GPCR类别 A
    宿主细胞 Chem-5
    蛋白靶 S1P5 / EDG8
    靶子系列 Lysophospholipid
    细胞系类型
    • Ready-to-Assay
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    • This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck-Millipore to request certain information about you and the establishment where the GMOs are being handled.
    包装信息
    数量 1 kit

    merck millipore,默克密理博,HTS193RTA,Ready-to-Assay™ S1P5 Lysophospholipid Receptor Frozen Cells

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