merck millipore,默克密理博,116850,Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6

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Merck Millipore 默克密理愽

merck millipore,默克密理博,116850,Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem

经验配方	CAS号
C₁₂H₁₁N₃O₂	299442-43-6

描述
概述	A cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC₅₀ = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of G_sα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.
产品目录编号	116850
品牌系列	Calbiochem®
同义词	2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone

参考
参考	Onda, T., et al. 2001. J. Biol. Chem. 276, 47785.

生物信息
主靶	Adenylate cyclase (AC) type V isoform
主靶IC₅₀	8.3 µM, 132 µM and 1.7 mM for type V, III and II, of adenylyl cyclase (AC), respectively, in the presence of Gsα GTPγS-Forskolin
纯度	≥97% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or MeOH

储存和货运信息
货运代码	Blue Ice Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,116850,Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem

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