merck millipore,默克密理愽
  • merck millipore,默克密理博,567630,Sodium Salicylate - CAS 54-21-7 - Calbiochem

  • merck millipore,默克密理博,567630,Sodium Salicylate - CAS 54-21-7 - Calbiochem

    产品名称：Sodium Salicylate - CAS 54-21-7 - Calbiochem
    产品型号：567630
    A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein.

    merck millipore,默克密理博,567630,Sodium Salicylate - CAS 54-21-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,567630,Sodium Salicylate - CAS 54-21-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₇H₅O₃ · Na54-21-7
    描述
    概述 A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.
    产品目录编号 567630
    品牌系列 Calbiochem®
    同义词 Salicylic Acid, Na, NaSal
    参考
    参考 Schwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
    Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
    Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
    Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
    Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.
    产品信息
    CAS号 54-21-7
    具有ATP竞争性 N
    形式 Off-white solid
    Hill配方 C₇H₅O₃ · Na
    化学配方 C₇H₅O₃ · Na
    Molar Mass 160.1
    吸湿 Hygroscopic
    可逆 N
    结构配方图像
    生物信息
    主靶 TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases
    纯度 ≥98% by titration
    理化信息
    细胞可渗透 Y
    溶解度 EtOH or H₂O
    GHS安全信息
    RTECS VO5075000
    安全信息
    R相 R: 22

    Harmful if swallowed.
    S相 S: 24/25

    Avoid contact with skin and eyes.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 +15°C to +30°C
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,567630,Sodium Salicylate - CAS 54-21-7 - Calbiochem

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