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经验配方 CAS号 C₁₆H₁₂FN₃S 72873-74-6 描述 概述 A cell-permeable, reversible, and ATP-competitive cytokine-suppressive anti-inflammatory drug (CSAID). A bicyclic imidazole that inhibits lipolysaccharide (LPS)-stimulated human monocyte IL-1 and TNF-α production (IC50 = 1 µM). Also acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. SKF-86002 also acts as a specific p38 MAP kinase inhibitor. 产品目录编号 567305 品牌系列 Calbiochem®
同义词 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridyl)imidazo[2,1-b]thiazole 参考 参考 Frasch, S.C., et al. 1998. J. Biol. Chem. 273, 8389.
Blanque, R., et al. 1997. Drugs Exp. Clin. Res. 23, 63.
Lee, J.C., et al. 1995. Nature 372, 739.
Prichett, W., et al. 1995. J. Inflamm. 45, 97.
Lee, J.C., et al. 1993. Ann. N.Y. Acad. Sci. 696, 149.产品信息 CAS号 72873-74-6 具有ATP竞争性 Y 形式 Off-white solid Hill配方 C₁₆H₁₂FN₃S 化学配方 C₁₆H₁₂FN₃S Molar Mass 297.4 可逆 Y 结构配方图像 生物信息 主靶 (LPS)-stimulated IL-1 and TNF-α production 主靶IC50 1 µM inhibiting lipolysaccharide (LPS)-stimulated human monocyte IL-1 and TNF-α production 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 安全信息 R相 R: 36/37/38
Irritating to eyes, respiratory system and skin.S相 S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
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