merck millipore,默克密理愽
  • merck millipore,默克密理博,559410,SB 290157 - CAS 1140525-25-2 - Calbiochem

  • merck millipore,默克密理博,559410,SB 290157 - CAS 1140525-25-2 - Calbiochem

    产品名称：SB 290157 - CAS 1140525-25-2 - Calbiochem
    产品型号：559410
    A non-peptide that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC₅₀ = 200 nM).

    merck millipore,默克密理博,559410,SB 290157 - CAS 1140525-25-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,559410,SB 290157 - CAS 1140525-25-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₂₈N₄O₄ · CF₃CO₂H1140525-25-2
    描述
    概述 A non-peptide that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC50 = 200 nM). Does not antagonize C5aR or other chemotactic G-protein-coupled receptors. Blocks C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR (IC50 = 7, 12.5, and 27.7 nM, respectively). Also blocks C3a-mediated ATP release from Guinea pig platelets (IC50 = 30 nM). Exhibits anti-inflammatory properties. Supplied as a trifluoroacetate salt.
    产品目录编号 559410
    品牌系列 Calbiochem®
    同义词 N²-[(2,2-Diphenylethoxy)acetyl]-L-arginine, TFA
    参考
    参考 Ames, R.S., et al. 2001. J. Immunol. 166, 6341.
    产品信息
    CAS号 1140525-25-2
    具有ATP竞争性 N
    形式 Lyophilized
    Hill配方 C₂₂H₂₈N₄O₄ · CF₃CO₂H
    化学配方 C₂₂H₂₈N₄O₄ · CF₃CO₂H
    Molar Mass 526.5
    吸湿 Hygroscopic
    可逆 N
    结构配方图像
    生物信息
    主靶 C3a receptor
    主靶IC50 200 nM against the anaphylatoxin C3a receptor; 7, 12.5, and 27.7 nM, in blocking C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 N
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Do not reuse solutions diluted in physiological buffers.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,559410,SB 290157 - CAS 1140525-25-2 - Calbiochem

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