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merck millipore,默克密理博,566332,Sirt1 Inhibitor VII, Inauhzin - Calbiochem
产品名称：Sirt1 Inhibitor VII, Inauhzin - Calbiochem
产品型号：566332
The Sirt1 Inhibitor VII, Inauhzin controls the biological activity of Sirt1. This small molecule/inhibitor is primarily used for Cell Structure applications.
merck millipore,默克密理博,566332,Sirt1 Inhibitor VII, Inauhzin - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₅H₁₉N₅OS₂ 描述 概述 A cell-permeable phenothiazine derivative that selectively inhibits SirT1 (IC50 ≤2.0 µM), but not SirT2, SirT3, or HCAC8 (IC50 >50 µM), activity. Effectively elevates cellular p53 lysine acetylation (Effective conc. 2 µM), thereby protecting p53 lysine residues from MDM2-mediated ubiquitination without inhibiting MDM2 activity toward deacetylated p53. Shown to inhibit cancer cell growth in a p53-dependent manner (IC50 = 2.0 and 15.7µM, respectively, against HCT116p53+/+ and HCT116p53-/- cells) and synergize with Nutlin-3 (Cat. Nos. 444143, 444151, & 444152) in blocking HCT116p53+/+ proliferation in vitro (1 µM INZ & 4 µM Nutlin-3) and inducing HCT116p53+/+ apoptosis in mice in vivo (15 mg INZ/kg/d i.p; 150 mg Nut-3/kg/12 h p.o.). 产品目录编号 566332 品牌系列 Calbiochem®
同义词 10-[2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)butanoyl]-10H-phenothiazine, INZ 参考 参考 Zhang, Q., et al. 2012. EMBO Mol. Med. 4, 298.
Zhang, Y., et al. 2012. Cancer Biol. Ther. 13, 915产品信息 形式 Beige powder Hill配方 C₂₅H₁₉N₅OS₂ 化学配方 C₂₅H₁₉N₅OS₂ Molar Mass 469.6 可逆 Y 结构配方图像 生物信息 主靶 Sirt1 主靶IC50 0.7&ndash 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,MRCF0R100,Microcon DNA Fast Flow Centrifugal Filter Unit with Ultracel membrane
下一件merck millipore产品：merck millipore,默克密理博,MAB1637,Anti-Tubulin Antibody, beta III isoform, CT, clone TU-20 (Similar to TUJ1)
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