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merck millipore,默克密理博,565794,InSolution™ β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem
产品名称：InSolution™ β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem
产品型号：565794
The InSolution™ β-Secretase Inhibitor, also referenced under CAS 797035-11-1, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applicat More>>
merck millipore,默克密理博,565794,InSolution™ β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₃₁H₃₈N₄O₅S 797035-11-1 描述 概述 A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). The solid form of this compound (Cat. No. 565788) is also available. 产品目录编号 565794 品牌系列 Calbiochem®
同义词 N-(1S, 2R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-5-(methyl(methylsulfonyl)amino-Nʹ-((1R)-1-phenylethyl)isophthalamide 参考 参考 Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447. 产品信息 CAS号 797035-11-1 形式 Liquid 配方 A 10 mM (500 µg/86.4 µL) solution of β-Secretase Inhibitor IV (Cat. No. 565788) in DMSO. Hill配方 C₃₁H₃₈N₄O₅S Molar Mass 578.7 吸湿 Hygroscopic
可逆 Y 结构配方图像 生物信息 主靶 β-Secretase 主靶IC50 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 安全信息 R相 R: 36/38
Irritating to eyes and skin.S相 S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.储存和货运信息 货运代码 Dry Ice Only
毒性 Irritant
储存 ≤ -70°C
避光 Protect from light
吸湿 Hygroscopic
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. For short term storage, aliquots are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,12-363,PRAK Substrate Peptide
下一件merck millipore产品：merck millipore,默克密理博,573099,STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem
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