merck millipore,默克密理愽
  • merck millipore,默克密理博,203890,CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem

  • merck millipore,默克密理博,203890,CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem

    产品名称：CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem
    产品型号：203890
    The CRAC Channel Inhibitor, BTP2, also referenced under CAS 223499-30-7, controls the biological activity of CRAC Channel. This small molecule/inhibitor is primarily used for Inflammation/Immunology a More>>

    merck millipore,默克密理博,203890,CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,203890,CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₉F₆N₅OS223499-30-7
    描述
    概述 A cell-permeable pyrazole that acts as a more potent blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 590 nM by Fura-2; peak current density pA/pF = -1.13 and -7.50, respectively, with or without 3 µM BTP2/Pyr2 by whole cell clamp) than the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca2+ entry) inTRPC3-expressing HEK293 cells (IC50 = 4.21 µM by Fura-2; pA/pF = -1.54 and -18.50, respectively, with or without 3 µM BTP2/Pyr2). A great complement to Pyr 3 (Cat. No. 648490), Pyr6, and Pyr10 in Ca2+ signaling studies.
    产品目录编号 203890
    品牌系列 Calbiochem®
    同义词 [N-{4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide], Pyr2, TPRC3 Channel Inhibitor II
    参考
    参考 Schleifier, H., et al. 2012. Br J Pharmacol In Press
    Yonetoku, Y., et al. 2006. Bioorg. Med. Chem. 14, 5370.
    Yonetoku, Y., et al. 2006. Bioorg. Med. Chem. 14, 4750.
    Zitt, C., et al. 2004. J. Biol. Chem. 279, 12927.
    Trevillyan, J.M., et al. 2001. J. Biol. Chem. 276, 48118.
    Djuric, S.W., et al. 2000. J. Med. Chem. 43, 2975.
    产品信息
    CAS号 223499-30-7
    具有ATP竞争性 N
    形式 Solid
    Hill配方 C₁₅H₉F₆N₅OS
    化学配方 C₁₅H₉F₆N₅OS
    Molar Mass 421.3
    可逆 N
    结构配方图像
    生物信息
    主靶 CRAC Channel
    主靶IC50 590 nM by Fura-2
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,203890,CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem

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