merck millipore,默克密理博,MAB3731,Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877

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merck millipore,默克密理博,MAB3731,Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877
产品名称：Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877
产品型号：MAB3731
Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877 detects level of Met/HGFR & has been published & validated for use in ELISA.

merck millipore,默克密理博,MAB3731,Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877

产品介绍

merck millipore,默克密理博,MAB3731,Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, H	ELISA	M	Purified	Monoclonal Antibody

描述
产品目录编号	MAB3731
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877
Alternate Names	c-Met, cmet, HGFR, RCCP2, met proto-oncogene (hepatocyte growth factor receptor) c-Met cmet HGFR RCCP2

产品信息
格式	Purified
演示	Protein G purified immunoglobulin. Liquid in PBS containing 0.09% sodium azide.

应用
应用	Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877 detects level of Met/HGFR & has been published & validated for use in ELISA.
主要应用	ELISA
应用说明	ELISA (direct): 1:1,000 Optimal working dilutions must be determined by the end user.

生物信息
免疫原品种	Synthetic phospho-peptide corresponding to residues surrounding Tyr1234/1235 of human Met.
表位	phospho-specific (Tyr1234/1235)
克隆	6AT1877
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	Reacts with Met/HGFR (Hepatocyte growth factor receptor) only when phosphorylated at Tyr1234 and Tyr1235. The Met receptor tyrosine kinase is the prototypical member of a small subfamily of growth factor receptors that when activated, induces mitogenic, motogenic, and morphogenic cellular responses. The ligand for Met is hepatocyte growth factor/scatter factor (HGF/SF) and while normal HGF/SF-Met signaling is required for embryonic development, abnormal Met signaling has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes.
同种型	IgG1
品种反应性	MouseHuman
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_000245.2
Entrez基因汇总	The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma.
基因符号	EC 2.7.10.1 MET AUTS9 c-Met RCCP2 HGFR
修改	Phosphorylation
UniProt编号	P08581
UniProt汇总	FUNCTION: SwissProt: P08581 # Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. SIZE: 1390 amino acids; 155527 Da SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DISEASE: SwissProt: P08581 # Activation of MET after rearrangement with the TPR gene produces an oncogenic protein. & Defects in MET may be associated with gastric cancer. & Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550]. & Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance. & Genetic variations in MET may be associated with susceptibility to autism type 1B (AUTS1B) [MIM:608636]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior. SIMILARITY: SwissProt: P08581 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 3 IPT/TIG domains. & Contains 1 protein kinase domain. & Contains 1 Sema domain.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.

储存和货运信息

存储条件

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.