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merck millipore,默克密理博,573099,STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem
产品名称：STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem
产品型号：573099
The STAT3 Inhibitor V, Stattic, also referenced under CAS 19983-44-9, controls the biological activity of STAT3.
merck millipore,默克密理博,573099,STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₈H₅NO₄S 19983-44-9 描述 概述 A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells). 产品目录编号 573099 品牌系列 Calbiochem®
同义词 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound 参考 参考 Schust, J., et al. 2006. Chem. Biol. 13, 1235. 产品信息 CAS号 19983-44-9 具有ATP竞争性 N 形式 Pale yellow solid Hill配方 C₈H₅NO₄S 化学配方 C₈H₅NO₄S Molar Mass 211.2 可逆 N 结构配方图像 生物信息 主靶 STAT3 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use. 包装信息 惰性气体下包装 Packaged under inert gas
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