merck millipore,默克密理愽
  • merck millipore,默克密理博,565765,γ₄₀-Secretase Inhibitor I - Calbiochem

  • merck millipore,默克密理博,565765,γ₄₀-Secretase Inhibitor I - Calbiochem

    产品名称：γ₄₀-Secretase Inhibitor I - Calbiochem
    产品型号：565765
    The γ₄₀-Secretase Inhibitor I controls the biological activity of γ₄₀-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

    merck millipore,默克密理博,565765,γ₄₀-Secretase Inhibitor I - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,565765,γ₄₀-Secretase Inhibitor I - Calbiochem

    重要规格表

    经验配方
    C₂₃H₃₄N₂O₅
    描述
    概述 A potent, cell-permeable, reversible γ-secretase inhibitor that preferentially appears to inhibit the secretion of Aβ1-40 (>90%) over Aβ1-42 (~15%). Aβtotal IC50 ~ 15 µM; Aβ1-40 IC50 ~ 22 µM; Aβ1-42 IC50 > 50 µM in CHO cells stable transfected with the cDNA encoding βAPP695. Reported to be about 10-fold more potent than Z-Val-Phe-CHO (MDL 28170; Cat. No. 208722).
    产品目录编号 565765
    品牌系列 Calbiochem®
    同义词 t-3,5-DMC-IL-CHO, N-trans-3,5-Dimethoxycinnamoyl)-Ile-leucinal
    参考
    参考 Higaki, J.N., et al. 1999. J. Med. Chem. 42, 3889.
    产品信息
    具有ATP竞争性 N
    形式 White lyophilized solid
    Hill配方 C₂₃H₃₄N₂O₅
    化学配方 C₂₃H₃₄N₂O₅
    Molar Mass 418.5
    肽序列 trans-3,5-DMC-Ile-Leu-CHO (DMC = Dimethoxycinnamoyl)
    可逆 Y
    生物信息
    主靶 secretion of Aβ₁₋₄₀
    主靶IC50 ~ 15 µM for Aβtotal; ~ 22 µM for Aβ1-40; < 50 µM for Aβ1-42 in CHO cells stable transfected with the cDNA encoding βAPP695
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    肽序列 trans-3,5-DMC-Ile-Leu-CHO (DMC = Dimethoxycinnamoyl)
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,565765,γ₄₀-Secretase Inhibitor I - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,475893,MES, Free Acid, ULTROL Grade - CAS 4432-31-9 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,580563,TCPOBOP - CAS 76150-91-9 - Calbiochem


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