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经验配方 CAS号 C₁₆H₈Cl₄N₂O₂ 76150-91-9 描述 概述 The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. Acts as a tumor promoter of murine hepatocarcinogenesis; activates orphan nuclear receptors mCAR (mouse Constitutive Androstane Receptor) and hPXR (human Pregnane X Receptor), but has little or no activity on hCAR and mPXR. Also suppresses the multidrug resistance gene expression in the mouse liver. 产品目录编号 580563 品牌系列 Calbiochem®
同义词 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene 参考 参考 Ledda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91.
Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122.
Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951.
Forman, B.M., et al. 1998. Nature 395, 612.
Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597.
Russell, A.L., et al. 1994. Int. J. Cancer 58, 550.
Smith, G., et al. 1993. Biochem. J. 289, 807.
Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153.
Poland, A., et al. 1980. Mol. Pharmacol. 18, 571.产品信息 CAS号 76150-91-9 具有ATP竞争性 N 形式 White solid Hill配方 C₁₆H₈Cl₄N₂O₂ 化学配方 C₁₆H₈Cl₄N₂O₂ Molar Mass 402.1 可逆 N 结构配方图像 生物信息 主靶 Cytochrome P450 (CYP)-inducing agents 纯度 ≥95% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO GHS安全信息 RTECS UT7145000 安全信息 R相 R: 40
Limited evidence of a carcinogenic effect.S相 S: 22-36
Do not breathe dust.
Wear suitable protective clothing.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Carcinogenic / Teratogenic
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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