merck millipore,默克密理愽
  • merck millipore,默克密理博,07-1317,Anti-phospho-Leptin receptor (Tyr1077) Antibody

  • merck millipore,默克密理博,07-1317,Anti-phospho-Leptin receptor (Tyr1077) Antibody

    产品名称：Anti-phospho-Leptin receptor (Tyr1077) Antibody
    产品型号：07-1317
    Detect phospho-Leptin receptor (Tyr1077) using this Anti-phospho-Leptin receptor (Tyr1077) Antibody validated for use in WB.

    merck millipore,默克密理博,07-1317,Anti-phospho-Leptin receptor (Tyr1077) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-1317,Anti-phospho-Leptin receptor (Tyr1077) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-1317
    描述 Anti-phospho-Leptin receptor (Tyr1077) Antibody
    Alternate Names
    • leptin receptor
    • CD295 antigen
    • OB receptor
    背景信息 Leptin (LEP; MIM 164160), an adipocyte-specific hormone that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure, acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family.
    产品信息
    格式 Affinity Purified
    控制
    • Leptin Receptor IP lysate.
    演示 Affinity purified rabbit serum in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect phospho-Leptin receptor (Tyr1077) using this Anti-phospho-Leptin receptor (Tyr1077) Antibody validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to mouse phosphoylated Leptin receptor at and around Tyr1077.
    表位 Tyr1077
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes phosphorylated Leptin receptor at Tyr1077.
    品种反应性 MouseHuman
    Species Reactivity Note Reacts with human. Predicted to react with mouse based on sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • AAC52421.1
    基因符号
    • OTTHUMP00000010694
    • CD295
    • DB
    • HuB219
    • LEP-R
    • OB-R
    • OBR
    • OTTHUMP00000010693
    修改
    • Phosphorylation
    纯化方法 Affinity Purfied
    UniProt编号
    • Q8TCD6
    UniProt汇总 FUNCTION:Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway By similarity.
    SUBUNIT STRUCTURE: On leptin stimulation, homodimerizes. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3 By similarity. Interaction with SOCS3 inhibits LRb signaling By similarity.
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.Isoform E: Secreted Probable.
    TISSUE SPECIFICITY: Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
    DOMAIN: The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs.
    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation.
    PTM:On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3 By similarity. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation.
    SEQUENCE SIMILARITIES: Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 4 fibronectin type-III domains.
    Contains 1 Ig-like (immunoglobulin-like) domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in Leptin Receptor IP lysate. (See below)
    Western Blot Analysis: 1:500 dilution of this antibody detected Leptin Receptor phosphorylated at Tyr1077 in Leptin Receptor IP lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C for up to 12 months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-1317,Anti-phospho-Leptin receptor (Tyr1077) Antibody

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