merck millipore,默克密理愽
  • merck millipore,默克密理博,07-581,Anti-phospho-IRF-3 (Ser398) Antibody

  • merck millipore,默克密理博,07-581,Anti-phospho-IRF-3 (Ser398) Antibody

    产品名称：Anti-phospho-IRF-3 (Ser398) Antibody
    产品型号：07-581
    Detect phospho-IRF-3 (Ser398) also known as Interferon regulatory factor 3 with Anti-phospho-IRF-3 (Ser398) Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in WB.

    merck millipore,默克密理博,07-581,Anti-phospho-IRF-3 (Ser398) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-581,Anti-phospho-IRF-3 (Ser398) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-581
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-IRF-3 (Ser398) Antibody
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Detect phospho-IRF-3 (Ser398) also known as Interferon regulatory factor 3 with Anti-phospho-IRF-3 (Ser398) Antibody (Rabbit Polyclonal Antibody), that has been demonstrated to work in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated, synthetic peptide corresponding to amino acids 388-402 (ENTVDLHISN[pS]HPLS) of human interferon regulatory factor-3 (IRF-3)
    宿主 Rabbit
    特异性 phospho-IRF-3
    同种型 IgG
    品种反应性 Human
    Species Reactivity Note Does not work in mouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001571
    Entrez基因汇总 IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.
    基因符号
    • IRF-3
    • IRF3
    修改
    • Phosphorylation
    纯化方法 Protein A purfied
    UniProt编号
    • Q14653
    UniProt汇总 FUNCTION: SwissProt: Q14653 # Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains.
    SIZE: 427 amino acids; 47219 Da
    SUBUNIT: Homodimer; phosphorylation-induced. Interacts with CREBBP. May interact with MAVS. Interacts with IKBKE and TBK1.
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.
    TISSUE SPECIFICITY: Expressed constitutively in a variety of tissues.
    PTM: Constitutively phosphorylated on many serines residues. C- terminal serine/threonine cluster is phosphorylated in response of induction by IKBKE and TBK1. Ser-385 and Ser-386 may be specifically phosphorylated in response to induction. An alternate model propose that the five serine/threonine residues between 396 and 405 are phosphorylated in response to a viral infection. Phosphorylation, and subsequent activation of IRF3 is inhibited by vaccinia virus protein E3.
    SIMILARITY: SwissProt: Q14653 ## Belongs to the IRF family. & Contains 1 tryptophan pentad repeat DNA-binding domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from vesicular stomatitis virus (VSV) infected A549 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,07-581,Anti-phospho-IRF-3 (Ser398) Antibody

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