merck millipore,默克密理愽
  • merck millipore,默克密理博,ABD41,Anti-Lymphoid-specific helicase (HELLS) Antibody

  • merck millipore,默克密理博,ABD41,Anti-Lymphoid-specific helicase (HELLS) Antibody

    产品名称：Anti-Lymphoid-specific helicase (HELLS) Antibody
    产品型号：ABD41
    Anti-Lymphoid-specific helicase (HELLS) Antibody is an antibody against Lymphoid-specific helicase (HELLS) for use in WB & IC.

    merck millipore,默克密理博,ABD41,Anti-Lymphoid-specific helicase (HELLS) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABD41,Anti-Lymphoid-specific helicase (HELLS) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABD41
    描述 Anti-Lymphoid-specific helicase (HELLS) Antibody
    Alternate Names
    • SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6
    • LSH
    • Lymphoid-specific helicase
    • Proliferation-associated SNF2-like protein
    背景信息 A member of the SNF2 family of chromatin remodeling proteins, Lymphoid-specific helicase (HELLS, also known as Lsh) assumes various roles in normal development, survival, de novo or maintenance DNA methylation, gene silencing, and heterochromatin formation and organization. It is shown to serve as cancer progression marker in conjunction with CEP55 and FOXM1 for the detection of head and neck squamous cell carcinoma (HNSCC). It is also reported that expression of Lsh is crucial for meiotic progression in mouse spermatocytes. Lsh is shown to directly associate with the 5' DMR of the Cdkn1c promoter, and thereby regulate its gene expression. Additionally, Lsh is reported as a regulator of repressive chromatin at retrotransposons, and is demonstrated to mediate the silencing of stem cell-specific genes such as Oct4.
    产品信息
    格式 Affinity Purified
    控制
    • HeLa nuclear extract
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Lymphoid-specific helicase (HELLS) Antibody is an antibody against Lymphoid-specific helicase (HELLS) for use in WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Western Blot Analysis: 0.1 µg/mL from a representative lot detected Lymphoid-specific helicase in NIH/3T3 and L6 cell lysates.

    Immunocytochemistry Analysis: 2 µg/mL from a representative lot detected Lymphoid-specific helicase in NIH/3T3, A431, and HeLa cells.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the coiled-coil region of human Lymphoid-specific helicase.
    表位 Coiled-coil region
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes the coiled-coil region of Lymphoid-specific helicase.
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_060533
    Entrez基因汇总 This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
    基因符号
    • SMARCA6
    • HELLS
    • PASG
    纯化方法 Affinity Purified
    UniProt编号
    • Q9NRZ9
    UniProt汇总 FUNCTION: Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis.

    SUBCELLULAR LOCATION: Nucleus. Note: Closely associated with pericentric heterochromatin.

    TISSUE SPECIFICITY: Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa nuclear extract.

    Western Blot Analysis: 0.1 µg/mL of this antibody detected Lymphoid-specific helicase in HeLa nuclear extract.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABD41,Anti-Lymphoid-specific helicase (HELLS) Antibody

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