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  • merck millipore,默克密理博,ABC69,Anti-Apoptosis-inducing factor 2 (AIFM2) Antibody

  • merck millipore,默克密理博,ABC69,Anti-Apoptosis-inducing factor 2 (AIFM2) Antibody

    产品名称：Anti-Apoptosis-inducing factor 2 (AIFM2) Antibody
    产品型号：ABC69
    Anti-Apoptosis-inducing factor 2 (AIFM2) Antibody detects level of Apoptosis-inducing factor 2 (AIFM2) & has been published & validated for use in WB.

    merck millipore,默克密理博,ABC69,Anti-Apoptosis-inducing factor 2 (AIFM2) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABC69,Anti-Apoptosis-inducing factor 2 (AIFM2) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABC69
    描述 Anti-Apoptosis-inducing factor 2 (AIFM2) Antibody
    Alternate Names
    • p53-responsive gene 3 protein
    • Apoptosis-inducing factor 2
    • Apoptosis-inducing factor homologous mitochondrion-associated inducer of death
    • Apoptosis-inducing factor-like mitochondrion-associated inducer of death
    背景信息 Apoptosis inducing factor 2 (AIFM2) is a flavoprotein oxidoreductase that binds to DNA in a sequence-independent manner and is a member of the FAD-dependent oxidoreductase family. Apoptosis inducing factor 2 is widely expressed in the heart and, to a much lesser extent, the liver and skeletal muscles. Overexpression of Apoptosis inducing factor 2 has been shown to induce apoptosis.
    产品信息
    格式 Affinity Purified
    控制
    • C2C12 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Apoptosis-inducing factor 2 (AIFM2) Antibody detects level of Apoptosis-inducing factor 2 (AIFM2) & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Apoptosis inducing factor 2.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 HumanMouse
    Species Reactivity Note Demonstrated to react with Mouse. Predicted to react with Human based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_116186
    Entrez基因汇总 This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010].
    基因符号
    • PRG3
    • AIFM2
    • AMID
    纯化方法 Affinity purified
    UniProt编号
    • Q9BRQ8
    UniProt汇总 FUNCTION: Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.

    COFACTOR: FAD. Binds 6-hydroxy-FAD non-covalently.

    SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion outer membrane

    TISSUE SPECIFICITY: Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells.

    INDUCTION: Expression detected at 4 hours after induction by p53/TP53. Down-regulated in a wide range of human tumors.

    SEQUENCE SIMILARITIES: Belongs to the FAD-dependent oxidoreductase family.
    产品使用声明
    质量保证 Evaluated by Western Blot in C2C12 cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected Apoptosis inducing factor 2 on 10 µg of C2C12 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABC69,Anti-Apoptosis-inducing factor 2 (AIFM2) Antibody

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