merck millipore,默克密理愽
  • merck millipore,默克密理博,559405,SB 225002 - CAS 182498-32-4 - Calbiochem

  • merck millipore,默克密理博,559405,SB 225002 - CAS 182498-32-4 - Calbiochem

    产品名称：SB 225002 - CAS 182498-32-4 - Calbiochem
    产品型号：559405
    A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2 (IL-8RB; IC₅₀ = 22 nM for the inhibition of ¹²⁵I-IL-8 binding to CXCR2).

    merck millipore,默克密理博,559405,SB 225002 - CAS 182498-32-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,559405,SB 225002 - CAS 182498-32-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₃H₁₀BrN₃O₄182498-32-4
    描述
    概述 A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2 (IL-8RB; IC50 = 22 nM for the inhibition of 125I-IL-8 binding to CXCR2). Shows ~150-fold selectivity over CXCR1. Inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROα in vitro and in vivo selectively blocks IL-8-induced neutrophil margination in rabbits. Reduces presenilin expression, inhibits γ-secretase activity, and blocks Aβ40/42 production and notch processing; further, demonstrates in vivo efficacy in mouse models.
    产品目录编号 559405
    品牌系列 Calbiochem®
    同义词 N-(2-Hydroxy-4-nitrophenyl)-Nʹ-(2-bromophenyl)urea, CXCR2 Antagonist II
    参考
    参考 Bakshi, P., et al. 2009. ACS Chem. Biol. in press.
    White, J.R., et al. 1998. J. Biol. Chem. 273, 10095.
    产品信息
    CAS号 182498-32-4
    具有ATP竞争性 N
    形式 Yellow solid
    Hill配方 C₁₃H₁₀BrN₃O₄
    化学配方 C₁₃H₁₀BrN₃O₄
    Molar Mass 352.1
    可逆 N
    结构配方图像
    生物信息
    主靶 CXCR2
    主靶IC50 22 nM for the inhibition of 125I-IL-8 binding to CXCR2
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 N
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,559405,SB 225002 - CAS 182498-32-4 - Calbiochem

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