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merck millipore,默克密理博,324516,eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem
产品名称:eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem
产品型号:324516
The eEF2K Inhibitor, A-484954, also referenced under CAS 142557-61-7, controls the biological activity of eEF2K Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphor More>>
merck millipore,默克密理博,324516,eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₃H₁₅N₅O₃ 142557-61-7 描述 概述 A cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines. 产品目录编号 324516 品牌系列 Calbiochem®
同义词 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954 参考 参考 Chen, Z., et al. 2011. J. Bio. Chem. 286, 43951. 产品信息 CAS号 142557-61-7 形式 Off-white powder Hill配方 C₁₃H₁₅N₅O₃ 化学配方 C₁₃H₁₅N₅O₃ Molar Mass 289.3 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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