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品种反应性 主要应用 宿主 格式 抗体类型 Rhesus Macaque, H, M, R, Chp WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE108 描述 Anti-Pygo1 Antibody Alternate Names - Pygopus homolog 1
背景信息 Wnt/Wingless signaling controls many fundamental processeses, such as cellular growth and fate, and is known to be involved in embryonic segmentation, limb development and CNS patterning. Wnt signaling is also shown to influence postembryonic regulation of stem cell numbers and stem cell differentiation in epithelia, such as those of the colon and skin.
Wnt transduction is mediated by the association of Beta-Catenin with nuclear TCF DNA binding factors, including legless (lgs) and pygopus (pygo). Whereas lgs enclodes BCL9, pygo encodes a Pygopus (Pygo), a PHD finger protein. It is reported that BCL9 acts as an adaptor protein that recruits and physically links Pygo to the Beta-Catenin-TCF Complex. It is demonstrated that the recruitment of Pygo is required for this respective complex to function as a transcriptional co-activator of specific target genes.产品信息 格式 Affinity Purified 控制 - Human placenta tissue lysate.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Pygo1 Antibody is a Rabbit Polyclonal Antibody for detection of Pygo1 also known as Pygopus homolog 1 & has been validated in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Pygopus homolog 1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Rhesus MacaqueHumanMouseRatChimpanzee Species Reactivity Note Demonstrated to react with Human, Mouse, Rat. Predicted to react with Chimpanzee and Rhesus Macaque based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_056432.1
基因符号 - PYGO1
纯化方法 Affinity purified UniProt编号 - Q9Y3Y4
UniProt汇总 FUNCTION: Involved in signal transduction through the Wnt pathway.
SUBUNIT STRUCTURE: Binds to BCL9 via The PHD-type zinc finger motiv, and thereby becomes part of the nuclear beta-catenin/TCF complex. Found in a complex with BCL9L, CDC73, CTNNB1 and PYGO1.
SUBCELLULAR LOCATION: Nucleus.产品使用声明 质量保证 Evaluated by Western Blot in human placenta tissue lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected Pygo1 in human placenta tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,71507,D-Tube™ Dialyzer Midi, MWCO 6-8 kDa
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