- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,559402,SB 218078 - CAS 135897-06-2 - Calbiochem
产品名称：SB 218078 - CAS 135897-06-2 - Calbiochem
产品型号：559402
A cell-permeable, ATP-competitive, and reversible indolocarbazole derivative that acts as a potent and selective inhibitor of checkpoint kinase (Chk1) in vitro. It inhibits Chk1 phosphorylation More>>
merck millipore,默克密理博,559402,SB 218078 - CAS 135897-06-2 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₄H₁₅N₃O₃ 135897-06-2 描述 概述 A cell-permeable, ATP-competitive, and reversible indolocarbazole derivative that acts as a potent and selective inhibitor of checkpoint kinase (Chk1) in vitro. It inhibits Chk1 phosphorylation of cdc25C with an IC50 of 15 nM. However, SB-218078 is a much weaker inhibitor of Cdc2 (IC50 = 250 nM) and PKC (IC50 = 1 µM). 产品目录编号 559402 品牌系列 Calbiochem®
同义词 9,10,11,12,-Tetrahydro-9,12-epoxy-1H-diindolo(1,2,3-fg:3ʹ,2ʹ,1ʹ-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1,3(2H)-dione, Chk1 Inhibitor I 参考 参考 Zhao, B., et al. 2002. J. Biol. Chem. 277, 46609.
Jackson, J.R., et al. 2000. Cancer Res. 60, 566产品信息 CAS号 135897-06-2 具有ATP竞争性 Y 形式 Yellow solid Hill配方 C₂₄H₁₅N₃O₃ 化学配方 C₂₄H₁₅N₃O₃ Molar Mass 393.4 可逆 Y 结构配方图像 生物信息 主靶 Chk1 主靶IC50 15 nM against Chk1 phosphorylation of cdc25C; 23 nM, 5.6 nM, 16 nM, against CDK1, CDK2, CDK4, respectively 纯度 ≥90% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,71531,T7 Phage Capture Plate
下一件merck millipore产品：merck millipore,默克密理博,HTS135M,ChemiSCREEN™ Membrane Preparation Recombinant Human GPR41 Free Fatty Acid Receptor
相关产品
merck millipore,默克密理博,AB5188-50UL,Anti-Potassium Channel Kv3.1b Antibody
merck millipore,默克密理博,AB9750,Anti-14-3-3 phospho Serine58 Antibody
merck millipore,默克密理博,SCM017,ENStem-A™ Neuronal Differentiation Medium
merck millipore,默克密理博,ABC291,Anti-FLI1 Antibody
merck millipore,默克密理博,71531,T7 Phage Capture Plate
merck millipore,默克密理博,07-635,Anti-phospho-BRCA1 (Ser1423) Antibody
merck millipore,默克密理博,FCCH100171,FlowCellect™ Autophagy LC3 Antibody-based Assay Kit (100 tests)
merck millipore,默克密理博,MAB1955,Anti-Integrin α4 Antibody, clone P4C2
