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merck millipore,默克密理博,AB9750,Anti-14-3-3 phospho Serine58 Antibody
产品名称：Anti-14-3-3 phospho Serine58 Antibody
产品型号：AB9750
Anti-14-3-3 phospho Serine58 Antibody detects level of 14-3-3 phospho Serine58 & has been published & validated for use in WB.
merck millipore,默克密理博,AB9750,Anti-14-3-3 phospho Serine58 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB9750 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-14-3-3 phospho Serine58 Antibody 产品信息 格式 Affinity Purified 演示 Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol. 应用 应用 Anti-14-3-3 phospho Serine58 Antibody detects level of 14-3-3 phospho Serine58 & has been published & validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:1,000 生物信息 免疫原品种 Synthetic peptide of amino acids surrounding the phosphoSerine 58 site of rat 14-3-3 Protein. 宿主 Rabbit 特异性 14-3-3 Protein, phosphoSerine58. The antibody recognizes a protein of ~29 kDa corresponding to 14-3-3 Protein, phosphoSerine58 in lysates from rat brainstem. Immunolabeling is blocked by the phosphopeptide used as the immunogen but not the corresponding non-phosphopeptide. 品种反应性 RatHuman Species Reactivity Note The immunogen sequence has 100% conservation with mouse and Xenopus. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006761.3
Entrez基因汇总 This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. 基因符号 - FLJ45465
- YWHAE
- KCIP-1
- MDS
- 14-3-3E
- MDCR
修改 - Phosphorylation
纯化方法 Immunoaffinity purified UniProt编号 - P62258
UniProt汇总 FUNCTION: SwissProt: P62258 # Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
SIZE: 255 amino acids; 29174 Da
SUBUNIT: Homodimer. Interacts with NDEL1 (By similarity). Interacts with HCV core protein.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SIMILARITY: SwissProt: P62258 ## Belongs to the 14-3-3 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer. 包装信息 数量 100 µL
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