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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-756 品牌系列 Upstate
商名 - Upstate
描述 Anti-Frizzled 5 Antibody Alternate Names - Fzd5
- Fz5
背景信息 The Wnt family consists of ligands involved in cell fate determination, organogenesis, and oncogenesis. The Wnt signal is thought to be transduced sequentially via a homolog of the frizzled family of receptors to GSK-3 (disheveled), β- and γ- catenin and finally to members of the Tcf/Lef-1 family of HMG box transcription factors. Frizzled 5 is believed to function as the receptor for the Wnt5a ligand. 产品信息 格式 Purified 控制 - Lysates from mouse liver, C2C12, Jurkat, and HUVEC
演示 Purified antibody in PBS with 0.05% sodium azide and 30% Glycerol 应用 应用 Anti-Frizzled 5 Antibody is an antibody against Frizzled 5 for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated, synthetic peptide derived from amino acids 564-585 of human Frizzled 5 (CTGRTPPGPAATYHKQVSLSHV). 表位 C-Terminus 宿主 Rabbit 特异性 Frizzled 5 (aka Fz5 or Fzd5) 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003459
Entrez基因汇总 Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. 基因符号 - FzE5
- FZD5
- HFZ5
- MGC129692
- hFz5
- DKFZP434E2135
- Fz-5
- Hfz5
- C2orf31
纯化方法 Protein A chromatography UniProt编号 - Q13467
UniProt汇总 FUNCTION: SwissProt: Q13467 # Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway.
SIZE: 585 amino acids; 64507 Da
SUBUNIT: Interacts with GOPC (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Note=Localized at the plasma membrane and also found at the Golgi (By similarity).
DOMAIN: SwissProt: Q13467 The PDZ-binding motif mediates interaction with GOPC (By similarity). & Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity). & The FZ domain is involved in binding with Wnt ligands (By similarity).
SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family. & Contains 1 FZ (frizzled) domain.产品使用声明 质量保证 Routinely evaluated by immunoblot on lysates from mouse liver, C2C12, Jurkat or HUVEC cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 200 µg
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