merck millipore,默克密理愽
  • merck millipore,默克密理博,559274,S6K1 Inhibitor II, DG2 - Calbiochem

  • merck millipore,默克密理博,559274,S6K1 Inhibitor II, DG2 - Calbiochem

    产品名称：S6K1 Inhibitor II, DG2 - Calbiochem
    产品型号：559274
    The S6K1 Inhibitor II, DG2 controls the biological activity of S6K1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,559274,S6K1 Inhibitor II, DG2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,559274,S6K1 Inhibitor II, DG2 - Calbiochem

    重要规格表

    经验配方
    C₁₆H₁₇BrN₆O
    描述
    概述 A cell-permeable pyrazolopyrimidine compound that acts as a potent, ATP-competitive and reversible inhibitor of S6K1 (p70 ribosomal protein S6 kinase 1; IC50 = 9.1 nM) with ~2,400 reduced activity towards Akt (IC50 = 22 µM). Shown to completely block rpS6-Ser240/244 phosphorylation in L6 cells at 2.5 µM without inducing pAkt-Thr308 and Ser473, and display substantial selectivity in a 219-kinase panel (1 µM of DG2 in the presence of 10 µM of ATP; IC50 ≥50%; Clk1, Clk2, Dyrk1A, Dyrk3, Flt3, Flt3-D835Y, Flt4, GSK-3α/β, KDR, MAP4K4, Mink1, PKA, PRKG1, PRKG2, Ret-V804L, Ret-Y791F, RSK1, RSK3, RSK2, MSK2, MSK1 and p70S6K).
    产品目录编号 559274
    品牌系列 Calbiochem®
    同义词 3-Bromo-4-(4-(2-methoxyphenyl)piperazin-1-yl)-1H-pyrazolo[3,4-d]-pyrimidine
    参考
    参考 Wang, B.T., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 15201.
    Okuzumi, T., et al. 2009. Nat. Chem. Biol. 5, 484.
    产品信息
    形式 Off-white solid
    Hill配方 C₁₆H₁₇BrN₆O
    化学配方 C₁₆H₁₇BrN₆O
    Molar Mass 389.3
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,559274,S6K1 Inhibitor II, DG2 - Calbiochem

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