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描述 产品目录编号 14-911M 商名 - Upstate
描述 Aurora C, active 概述 Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. 产品信息 演示 Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. 应用 主要应用 - Kinase Assay
生物信息 来源 N-terminal 6His-tagged, recombinant, human Aurora C amino acids 35-end and N-terminal GST-tagged, recombinant, human INCENP, amino acids 821–end. Co-expressed by baculovirus in Sf21 insect cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_020238.2
基因符号 - Aur3
- AURKC
- AurC
- STK13
纯化方法 Purified using Ni2+/NTA agarose UniProt编号 - Q9UQB9
产品使用声明 质量保证 Routinely evaluated by phosphorylation of the peptide AKRRRLSSLRA 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 250 µg 包装 Also available in 10μg size as catalog # 14-911 and in 250 μg as catalog # 14-911-K.
上一件merck millipore产品：merck millipore,默克密理博,04-1019,Anti-Synaptophysin (CT) Antibody, clone YE269, rabbit monoclonal
下一件merck millipore产品：merck millipore,默克密理博,AB10206,Anti-NLK Antibody
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