merck millipore,默克密理愽
  • merck millipore,默克密理博,554716,REV-ERBα Agonist, GSK4112 - Calbiochem

  • merck millipore,默克密理博,554716,REV-ERBα Agonist, GSK4112 - Calbiochem

    产品名称：REV-ERBα Agonist, GSK4112 - Calbiochem
    产品型号：554716
    The REV-ERBα Agonist, GSK4112 controls the biological activity of REV-ERBα. This small molecule/inhibitor is primarily used for Biochemicals applications.

    merck millipore,默克密理博,554716,REV-ERBα Agonist, GSK4112 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,554716,REV-ERBα Agonist, GSK4112 - Calbiochem

    重要规格表

    经验配方
    C₁₈H₂₁ClN₂O₄S
    描述
    概述 A selective, cell-permeable ligand (EC50 = 250 nM) that acts as a REV-ERBα agonist using a FRET assay. It enhances the recruitment of NCoR peptide to REV-ERBα by up to 70%, and displays no activity towards LRH1, SF1, FXR or ROR, and LXR. Furthermore, it inhibits the promoter activity of Pai1, a known target for REV-ERBα by 30%. This ligand exhibits acute suppression of Bmal1 transcription, and is capable of resetting the molecular rhythm of REV-ERBα-mediated PER2 expression in both Rat-1 lung fibroblasts and on ectopic lung tissues in Luciferase reporter assays. In addition, it is shown to repress the expression of gluconeogenic genes in liver cells and reduce glucose output in primary hepatocytes.
    产品目录编号 554716
    品牌系列 Calbiochem®
    同义词 GSK4112
    参考
    参考 Grant, D., et al. 2010, ACS Chem. Biol. 5, 925.
    Meng, Q., et al. 2008. Journ. Cell. Sci 121, 3629.
    产品信息
    形式 Dark beige solid
    Hill配方 C₁₈H₂₁ClN₂O₄S
    化学配方 C₁₈H₂₁ClN₂O₄S
    Molar Mass 396.89
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,554716,REV-ERBα Agonist, GSK4112 - Calbiochem

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