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  • merck millipore,默克密理博,GF136,BAFF Protein, Recombinant human

  • merck millipore,默克密理博,GF136,BAFF Protein, Recombinant human

    产品名称：BAFF Protein, Recombinant human
    产品型号：GF136
    The Human BAFF protein (B-cell activating factor belonging to the TNF family) is a novel ligand in the TNF family.

    merck millipore,默克密理博,GF136,BAFF Protein, Recombinant human

  • 产品介绍
  • merck millipore,默克密理博,GF136,BAFF Protein, Recombinant human

    重要规格表

    主要应用 品种 来源 纯度
    CULTHumanE.coliGreater than 98% by SDS-PAGE. Endotoxin level is less than 0.1 ng per μg (1 EU/ug) of BAFF.
    描述
    产品目录编号 GF136
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 BAFF Protein, Recombinant human
    概述 Human BAFF (B-cell activating factor belonging to the TNF family) is a novel ligand in the TNF family. BAFF plays an important role as co-stimulator of B-cell proliferation and function. Recombinant human BAFF is a soluble 17.0 kDa protein containing 153 amino acid residues, comprising the TNF-like extracellular domain of BAFF.
    Alternate Names
    • BLyS
    • B-cell Activation Factor
    • TALL-1
    • THANK
    产品信息
    演示 Lyophilized from sterile filtered 0.5X PBS, pH 7.5, and 0.5 mM DTT, containing no additives.
    应用
    应用 The Human BAFF protein (B-cell activating factor belonging to the TNF family) is a novel ligand in the TNF family.
    主要应用
    • Cell Culture
    生物信息
    纯度 Greater than 98% by SDS-PAGE. Endotoxin level is less than 0.1 ng per μg (1 EU/ug) of BAFF.
    来源 E.coli
    品种 Human
    特异活性 Human BAFF is biologically active when compared to standards. The ED50 as determined by its dose-dependent mitogenic activity on human RPMI 8226 cells is 5-10 ng/mL.
    Entrez基因编号
    • NM_006573.3
    Entrez基因汇总 The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells.
    基因符号
    • BLYS
    • TNFSF13B
    • BLyS
    • TNFSF20
    • CD257
    • BAFF
    • TALL1
    • DTL
    • TALL-1
    • ZTNF4
    • THANK
    UniProt编号
    • Q9Y275
    UniProt汇总 FUNCTION: SwissProt: Q9Y275 # Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
    SIZE: 285 amino acids; 31223 Da
    SUBUNIT: Homotrimer.
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. & Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted.
    TISSUE SPECIFICITY: Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas.
    PTM: The soluble form derives from the membrane form by proteolytic processing. & N-glycosylated.
    SIMILARITY: SwissProt: Q9Y275 ## Belongs to the tumor necrosis factor family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 The lyophilized powder is stable for a few weeks at room temperature, but best stored at -20°C for up to one year from date of receipt. Reconstituted material can be stored at 2°-8°C for one week, but undiluted aliquots at -20°C are recommended. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 20 µg

    merck millipore,默克密理博,GF136,BAFF Protein, Recombinant human

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