merck millipore,默克密理愽
  • merck millipore,默克密理博,06-554,Anti-STAT5B Antibody

  • merck millipore,默克密理博,06-554,Anti-STAT5B Antibody

    产品名称：Anti-STAT5B Antibody
    产品型号：06-554
    Anti-STAT5B Antibody is a Rabbit Polyclonal Antibody for detection of STAT5B also known as signal transducer & activator of transcription 5B & has been tested in WB.

    merck millipore,默克密理博,06-554,Anti-STAT5B Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-554,Anti-STAT5B Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 06-554
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-STAT5B Antibody
    产品信息
    格式 Purified
    演示 0.1M Tris-Glycine, pH 7.4, 0.15M NaCl containing 0.05% sodium azide
    应用
    应用 Anti-STAT5B Antibody is a Rabbit Polyclonal Antibody for detection of STAT5B also known as signal transducer & activator of transcription 5B & has been tested in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 amino acids 774-787 of human STAT5B (CGRPMDSQWIPHAQS)
    宿主 Rabbit
    特异性 STAT5B
    同种型 IgG
    品种反应性 MouseHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_012448
    Entrez基因汇总 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
    基因符号
    • STAT5
    • STAT5B
    纯化方法 Protein A chromatography
    UniProt编号
    • P51692
    UniProt汇总 FUNCTION: SwissProt: P51692 # Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
    SIZE: 787 amino acids; 89866 Da
    SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.
    SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in response to phosphorylation (By similarity).
    PTM: Tyrosine phosphorylated (By similarity).
    DISEASE: SwissProt: P51692 # Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.
    SIMILARITY: SwissProt: P51692 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on mouse 3T3/A31 or human A431 cell lysates
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,06-554,Anti-STAT5B Antibody

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