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经验配方 CAS号 C₁₄H₁₂O₃ 501-36-0 描述 概述 A phenolic product found in both grape skins and wines. Has antifungal, antitumor, and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µM) and acts as an anti-mutagenic agent (ED50 = 15 µM) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells. 产品目录编号 554325 品牌系列 Calbiochem®
同义词 trans-3,4ʹ,5-Trihydroxystilbene 参考 参考 Howitz, K.T., et al. 2003. Nature 425, 191.
Lin, H.Y., et al. 2002. J. Urol. 168, 748.
Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262, 20.
Jang, M., et al. 1997. Science 275, 218.
Chen, C.K., et al. 1996. Gen. Pharmacol. 27, 363.产品信息 CAS号 501-36-0 具有ATP竞争性 N 形式 Off-white solid Hill配方 C₁₄H₁₂O₃ 化学配方 C₁₄H₁₂O₃ Molar Mass 228.2 可逆 N 结构配方图像 生物信息 主靶 COX-1 主靶IC50 ED50 = 15 µM against COX-1 纯度 ≥98% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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