merck millipore,默克密理博,422720,L-744,832 - CAS 1177806-11-9

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merck millipore,默克密理博,422720,L-744,832 - CAS 1177806-11-9 - Calbiochem
产品名称：L-744,832 - CAS 1177806-11-9 - Calbiochem
产品型号：422720
A cell-permeable potent and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor with anti-tumor properties.

merck millipore,默克密理博,422720,L-744,832 - CAS 1177806-11-9 - Calbiochem

产品介绍

merck millipore,默克密理博,422720,L-744,832 - CAS 1177806-11-9 - Calbiochem

重要规格表

经验配方	CAS号
C₂₆H₄₅N₃O₆S₂ · 2HCl	1177806-11-9

描述
概述	A cell-permeable potent and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor with anti-tumor properties. Rapidly blocks p70S6K activation and DNA synthesis and promotes apoptosis in transgenic mice. Induces p21 expression and cell cycle arrest in the G₁ phase. Displays synergistic effect with paclitaxel and epothilones in inhibiting tumor growth. Also mimics many of the effects of Rapamycin (Cat. No. 553210) and may be effective against tumors that exhibit inappropriate activation of the mTOR/p70S6K pathway.
产品目录编号	422720
品牌系列	Calbiochem®
同义词	(2S)-2-[[(2S)-2-[(2S,3S)-2-[(2R)-2-Amino-3-mercaptopropyl]amino]-3-methylpentyl]oxy]-1-oxo-3-phenylpropyl]amino]-4-(methylsulfonyl)-butanoic Acid 1-Methylethyl Ester, L-744,382

参考
参考	Law, B.K., et al. 2000. J. Biol. Chem. 275, 10796. Law, B.K., et al. 1999. J. Biol. Chem. 274, 4743. Barrington, R.E., et al. 1998. Mol. Cell. Biol. 18, 85. Moasser, M.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 1369. Sepp-Lorenzino, L., and Rosen, N. 1998. J. Biol. Chem. 273, 20243. Kohl, N.E., et al. 1995. Nat. Med. 1, 792. Sepp-Lorenzino, L., et al. 1995. Cancer Res. 55, 5302.

参考

Law, B.K., et al. 2000. J. Biol. Chem. 275, 10796.
Law, B.K., et al. 1999. J. Biol. Chem. 274, 4743.
Barrington, R.E., et al. 1998. Mol. Cell. Biol. 18, 85.
Moasser, M.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 1369.
Sepp-Lorenzino, L., and Rosen, N. 1998. J. Biol. Chem. 273, 20243.
Kohl, N.E., et al. 1995. Nat. Med. 1, 792.
Sepp-Lorenzino, L., et al. 1995. Cancer Res. 55, 5302.

产品信息
CAS号	1177806-11-9
具有ATP竞争性	N
形式	White solid
Hill配方	C₂₆H₄₅N₃O₆S₂ · 2HCl
化学配方	C₂₆H₄₅N₃O₆S₂ · 2HCl
Molar Mass	632.7
吸湿	Hygroscopic
可逆	N
结构配方图像

生物信息
主靶	Farnesyltransferase (FTase)
纯度	≥98% by TLC

理化信息
细胞可渗透	Y
溶解度	DMSO or H₂O

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.