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merck millipore,默克密理博,ABS16,Anti-GAPDH Antibody
产品名称：Anti-GAPDH Antibody
产品型号：ABS16
Anti-Glyceraldehyde-3-Phosphate Dehydrogenase Antibody is popular affinity purified polyclonal antibody. This antibody is supported by peer reviewed publications and reliably detects Glyceraldehyde-3 More>>
merck millipore,默克密理博,ABS16,Anti-GAPDH Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Gp, H, M, R, B WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS16 描述 Anti-GAPDH Antibody Alternate Names - EC 1.2.1.12
- glyceraldehyde 3-phosphate dehydrogenase
- aging-associated gene 9 protein
- glyceraldehyde-3-phosphate dehydrogenase, GAPDH
- G3PDH
- GAPD
- OK/SW-cl.12
- MGC88685
- G3PD
背景信息 Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is an ubiquitous glycolytic enzyme present in moderately high levels in almost all tissues. As a 'house-keeping' enzyme, it catalyzes the synthesis of 1,3-biphosphoglycerate, a "high energy" intermediate used for the synthesis of ATP. Besides its cytoplasmic action in metabolism it is also involved in the initial stages of apoptosis or oxidative stress response where GAPDH is translocated to the nucleus. Such actions may reflect the role of GAPDH in DNA repair or as one nuclear carrier for apoptotic molecules. GAPDH has also been found to bind specifically to proteins implicated in the pathogenesis of a variety of neurodegenerative disorders including the beta-amyloid precursor protein and the huntingtin protein where decreased function of GAPDH is associated with Alzheimer's and Huntington's disease fibroblasts. GAPDH has also been identified as a potential target for nitric oxide (NO)-mediated cellular toxicity. The complete and functional enzyme is a tetramer with each of four identical subunits occupying the vertex of a tetrahedron. Binding domains also include one principally interacting with NAD+ and another interacting with glyceraldehyde 3-phosphate (GAP). 产品信息 格式 Affinity Purified 控制 - HEK293 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Glyceraldehyde-3-Phosphate Dehydrogenase Antibody is popular affinity purified polyclonal antibody. This antibody is supported by peer reviewed publications and reliably detects Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) is validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the C-terminus of human GAPDH. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes GAPDH at the C-terminus. 品种反应性 Guinea PigHumanMouseRatBovine Species Reactivity Note Demonstrated to react with human, mouse, and rat. Predicted to react with bovine and guinea pig based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_002037
Entrez基因汇总 The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. [provided by RefSeq]. 基因符号 - G3PD
- GAPDH
- G3PDH
- GAPD
纯化方法 Affinity purified UniProt编号 - P04406
UniProt汇总 FUNCTION: Independent of its glycolytic activity it is also involved in membrane trafficking in the early secretory pathway.
SIZE: 335 amino acids; 36053 Da
SUBUNIT: Homotetramer. Binds PRKCI.
SUBCELLULAR LOCATION: Cytoplasm. Note=Postnuclear and Perinuclear regions. Membrane.
SIMILARITY: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.产品使用声明 质量保证 Evaluated by Western Blot in HEK293 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected GAPDH on 10 µg of HEK293 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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