merck millipore,默克密理博,553210,Rapamycin - CAS 53123-88-9

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merck millipore,默克密理博,553210,Rapamycin - CAS 53123-88-9 - Calbiochem
产品名称：Rapamycin - CAS 53123-88-9 - Calbiochem
产品型号：553210
Rapamycin, also referenced under CAS 53123-88-9, modulates the biological activity of mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

merck millipore,默克密理博,553210,Rapamycin - CAS 53123-88-9 - Calbiochem

产品介绍

merck millipore,默克密理博,553210,Rapamycin - CAS 53123-88-9 - Calbiochem

重要规格表

经验配方	CAS号
C₅₁H₇₉NO₁₃	53123-88-9

描述
概述	Anti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC₅₀ = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser⁴⁷³ appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110^Rb phosphorylation, p34^cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G₁ phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G₁ phase. A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available.
产品目录编号	553210
品牌系列	Calbiochem®
同义词	mTOR Inhibitor I

参考
参考	Chen, T., et al. 2011. Aging Cell. 10, 908. Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794. Braun, W., et al. 1995. FASEB J. 9, 63. Nielsen, F.C., et al. 1995. Nature 377, 358. Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493. Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350. Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734. Terada, N., et al. 1993. J. Biol. Chem. 268, 12062. Kuo, J., et al. 1992. Nature 358, 70. Price, D.J., et al. 1992. Science 257, 973. Heitman, J., et al. 1991. Science 253, 905. Kay, J.E., et al. 1991. Immunology 72, 544. Schreiber, S.L. 1991. Science 251, 283. Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231. Dumont, F.J., et al. 1990. J. Immunol. 144, 251.

参考

Chen, T., et al. 2011. Aging Cell. 10, 908.
Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
Braun, W., et al. 1995. FASEB J. 9, 63.
Nielsen, F.C., et al. 1995. Nature 377, 358.
Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
Kuo, J., et al. 1992. Nature 358, 70.
Price, D.J., et al. 1992. Science 257, 973.
Heitman, J., et al. 1991. Science 253, 905.
Kay, J.E., et al. 1991. Immunology 72, 544.
Schreiber, S.L. 1991. Science 251, 283.
Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
Dumont, F.J., et al. 1990. J. Immunol. 144, 251.

产品信息
CAS号	53123-88-9
具有ATP竞争性	N
形式	Clear film
Hill配方	C₅₁H₇₉NO₁₃
化学配方	C₅₁H₇₉NO₁₃
Molar Mass	914.2
可逆	N
结构配方图像

生物信息
主靶	Mammalian target of rapamycin (mTOR)
主靶IC₅₀	50 pM against p70 S6 kinase
纯度	≥99% by HPLC

理化信息
细胞可渗透	N
溶解度	DMSO or MeOH

GHS安全信息
RTECS	VE6250000

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.