merck millipore,默克密理博,528118,PI 3-Kδ Inhibitor X, IC87114 - CAS 371242-69-2

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Merck Millipore 默克密理愽

merck millipore,默克密理博,528118,PI 3-Kδ Inhibitor X, IC87114 - CAS 371242-69-2 - Calbiochem

经验配方	CAS号
C₂₂H₁₉N₇O	371242-69-2

描述
概述	A cell permeable, selective inhibitor of PI 3-Kδ (IC₅₀= 1.82, 0.07, and 1.24 for p110b, p110d, and p110g, respectively, but may also target p110a at concentrations as high as 100 µM with less potency) in NB-4 and primary APL cells. It has been reported that the constitutive activation of PI3K/Akt signaling in primary AML cells is predominantly attributable to PI 3-Kδ. Pharmacologic use of PI 3-Kδ inhibitor has been shown to block PI3K/Akt/mTOR signaling and could thereby reduce proliferation and induce apoptosis. A related study further suggests PI 3-Kδ inhibitor as a key therapeutic target among PI 3-K isoforms for allergy- and mast cell-related diseases.
产品目录编号	528118
品牌系列	Calbiochem®
同义词	Phosphatidylinositol 3-Kinase p110d Inhibitor, PI 3-K Inhibitor X

参考
参考	Billottet, C., et al. 2009. Cancer Res. 69,1027. Ali, K., et al. 2008. J. Immunol. 180, 2538.

生物信息
纯度	≥95% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Blue Ice Only
毒性	Standard Handling
储存	-20°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

merck millipore,默克密理博,528118,PI 3-Kδ Inhibitor X, IC87114 - CAS 371242-69-2 - Calbiochem

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