merck millipore,默克密理愽
  • merck millipore,默克密理博,373277,Hh Signaling Antagonist XI, MRT-14 - Calbiochem

  • merck millipore,默克密理博,373277,Hh Signaling Antagonist XI, MRT-14 - Calbiochem

    产品名称：Hh Signaling Antagonist XI, MRT-14 - Calbiochem
    产品型号：373277
    The Hh Signaling Antagonist XI, MRT-14 controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.

    merck millipore,默克密理博,373277,Hh Signaling Antagonist XI, MRT-14 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,373277,Hh Signaling Antagonist XI, MRT-14 - Calbiochem

    重要规格表

    经验配方
    C₂₄H₂₃N₃O₆
    描述
    概述 A cell-permeable acylurea compound that acts as an antagonistic Smo ligand (IC50 = 120 nM against 5 nM Bodipy-cyclopamine binding to murine Smo-transfected HEK293 cells) and is more effective than Cyclopamine (Cat. No. 239803) in inhibiting ShhN-induced Gli transcription in Shh-light 2 cell assays (IC50 = 0.16 and 0.3 µM, respectively) and in blocking 0.1 µM SAG- (Cat. Nos. 566660 & 566661) stimulated differentiation of C3H10T1/2 murine mesenchymal stem cells into osteoblasts (IC50 = 0.13 and 0.62 µM, respectively).
    产品目录编号 373277
    品牌系列 Calbiochem®
    同义词 N-(3-Benzamidophenylcarbamoyl)-3,4,5-trimethoxybenzamide, Smo Antagonist VIII
    参考
    参考 Manetti, F., et al. 2010. Mol. Pharmacol. 78, 658.
    产品信息
    形式 White powder
    Hill配方 C₂₄H₂₃N₃O₆
    化学配方 C₂₄H₂₃N₃O₆
    Molar Mass 449.5
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,373277,Hh Signaling Antagonist XI, MRT-14 - Calbiochem

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