merck millipore,默克密理愽
  • merck millipore,默克密理博,681673,Wnt Antagonist III, Box5 - Calbiochem

  • merck millipore,默克密理博,681673,Wnt Antagonist III, Box5 - Calbiochem

    产品名称：Wnt Antagonist III, Box5 - Calbiochem
    产品型号：681673
    The Wnt Antagonist III, Box5 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

    merck millipore,默克密理博,681673,Wnt Antagonist III, Box5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,681673,Wnt Antagonist III, Box5 - Calbiochem

    重要规格表

    经验配方
    C₃₀H₅₀N₆O₁₃S₂
    描述
    概述 A Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
    产品目录编号 681673
    品牌系列 Calbiochem®
    同义词 Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist, Wnt-5a Antagonist
    参考
    参考 Jenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473.
    Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.
    产品信息
    形式 White lyophilized solid
    Hill配方 C₃₀H₅₀N₆O₁₃S₂
    化学配方 C₃₀H₅₀N₆O₁₃S₂
    Molar Mass 766.9
    肽序列 t-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
    生物信息
    纯度 ≥90% by HPLC
    理化信息
    溶解度 DMSO or H₂O
    肽序列 t-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,681673,Wnt Antagonist III, Box5 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,420322,IPTG, Dioxane-Free, High Purity - CAS 367-93-1 - Calbiochem


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