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  • merck millipore,默克密理博,AB5436P,Anti-Brain and Muscle ARNT-Like 1 Antibody

  • merck millipore,默克密理博,AB5436P,Anti-Brain and Muscle ARNT-Like 1 Antibody

    产品名称：Anti-Brain and Muscle ARNT-Like 1 Antibody
    产品型号：AB5436P
    Anti-Brain & Muscle ARNT-Like 1 Antibody is a Rabbit Polyclonal Antibody for detection of Brain & Muscle ARNT-Like 1 also known as BMAL1, MOP3/CYCLE & has been validated in ELISA & WB.

    merck millipore,默克密理博,AB5436P,Anti-Brain and Muscle ARNT-Like 1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5436P,Anti-Brain and Muscle ARNT-Like 1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    DrWB, ELISARbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5436P
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Brain and Muscle ARNT-Like 1 Antibody
    Alternate Names
    • MOP3/CYCLE
    • BMAL1
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.4, containing 0.1% BSA and 0.1% sodium azide.
    应用
    应用 Anti-Brain & Muscle ARNT-Like 1 Antibody is a Rabbit Polyclonal Antibody for detection of Brain & Muscle ARNT-Like 1 also known as BMAL1, MOP3/CYCLE & has been validated in ELISA & WB.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Western blot: 1-10 μg/mL using ECL.

    ELISA: 0.5-1 μg/mL using 1 μg/mL control peptide per well.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 A 22 amino acid peptide of drosophila BMAL1 (Darlington et al. 1998; Rutila et al. 1998; Bae et al. 1998). Gene accession # 3219728.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes drosophila BMAL1. The immunogen shows no significant sequence homology with mammalian Clock or Per proteins. Significant homology is seen with mammalian USF's (Upstream Stimulatory Factors 1 and 2) and human and mouse BMAL1 and ARNTs.

    SPECIES REACTIVITIES: The immunogen sequence has no homology with mammalian Clock or Per proteins. Reactivity with other species has not been confirmed.
    品种反应性 Drosophila
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001178.4
    • NM_001030272.1
    • NM_001030273.1
    Entrez基因汇总 The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.
    基因符号
    • MGC47515
    • ARNTL
    • BMAL1
    • MOP3
    • BMAL1c
    • TIC
    • PASD3
    • JAP3
    UniProt编号
    • O00327
    UniProt汇总 FUNCTION: SwissProt: O00327 # BMAL1-CLOCK heterodimers activate E-box element (3'- CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity).
    SIZE: 626 amino acids; 68762 Da
    SUBUNIT: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and BMAL1. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-BMAL1 heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in vivo.
    SUBCELLULAR LOCATION: Nucleus (By similarity).
    TISSUE SPECIFICITY: Highly expressed in the adult brain, skeletal muscle and heart.
    PTM: Phosphorylated upon dimerization with CLOCK (By similarity). & Sumoylated on Lys-259 upon dimerization with CLOCK (By similarity).
    SIMILARITY: SwissProt: O00327 ## Contains 1 basic helix-loop-helix (bHLH) domain. & Contains 1 PAC (PAS-associated C-terminal) domain. & Contains 2 PAS (PER-ARNT-SIM) domains.
    MISCELLANEOUS: CLOCK-BMAL1 double mutations within the PAS domains result in syngernistic desensitization to high levels of CRY on repression of CLOCK-BMAL1 transcriptional activity of PER1 and, disrupt circadian rhythmicity.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB5436P,Anti-Brain and Muscle ARNT-Like 1 Antibody

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