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  • merck millipore,默克密理博,07-1517,Anti-phospho-IRS-2 (Ser388) Antibody

  • merck millipore,默克密理博,07-1517,Anti-phospho-IRS-2 (Ser388) Antibody

    产品名称：Anti-phospho-IRS-2 (Ser388) Antibody
    产品型号：07-1517
    Anti-phospho-IRS-2 (Ser388) Antibody detects level of phospho-IRS-2 (Ser388) & has been published & validated for use in Western Blotting, Peptide Inhibition Assay.

    merck millipore,默克密理博,07-1517,Anti-phospho-IRS-2 (Ser388) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-1517,Anti-phospho-IRS-2 (Ser388) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-1517
    描述 Anti-phospho-IRS-2 (Ser388) Antibody
    Alternate Names
    • IRS-2
    • Insulin receptor substrate 2
    背景信息 Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling and play a central role in maintaining basic cellular functions such as growth, survival, and metabolism. They act as docking proteins between the insulin receptor and a complex network of intracellular signaling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified that differ as to tissue distribution, subcellular localization, developmental expression, binding to the insulin receptor, and interaction with SH2 domain-containing proteins. In fact, IRS-1 appears to have its major role in skeletal muscle whereas IRS-2 appears to regulate hepatic insulin action as well as pancreatic beta cell development and survival. By contrast, IRS-3 and IRS-4 genes appear to play a redundant role in the IRS signaling system. Defects in muscle IRS-1 expression and function have been reported in insulin-resistant states such as obesity and type 2 diabetes.
    产品信息
    格式 Affinity Purified
    控制
    • Untreated and insulin treated HEK293 cell lysates
    演示 Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-phospho-IRS-2 (Ser388) Antibody detects level of phospho-IRS-2 (Ser388) & has been published & validated for use in Western Blotting, Peptide Inhibition Assay.
    主要应用
    • Western Blotting
    应用说明 Peptide Inhibition Assay Analysis: 10 µg from a representative lot blocked IRS-2 on insulin treated HEK293 cells.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human IRS-2 phosphorylated Ser388.
    表位 Phosphorylated Ser388
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes IRS-2 phosphorylated at Ser388.
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_003740
    基因符号
    • IRS2
    纯化方法 Affinity purified
    UniProt编号
    • Q9Y4H2
    产品使用声明
    质量保证 Evaluated by Western Blot in untreated and insulin treated HEK293 cell lysates.

    Western Blot Analysis: 5 µg/mL of this antibody detected IRS-2 on 10 µg of untreated and insulin treated HEK293 cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,07-1517,Anti-phospho-IRS-2 (Ser388) Antibody

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