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merck millipore,默克密理博,525143,cPLA2α Inhibitor - Calbiochem
产品名称：cPLA2α Inhibitor - Calbiochem
产品型号：525143
The cPLA2α Inhibitor controls the biological activity of cPLA2α. This small molecule/inhibitor is primarily used for Cell Signaling applications.
merck millipore,默克密理博,525143,cPLA2α Inhibitor - Calbiochem
- 产品介绍
重要规格表
经验配方 C₄₉H₄₄F₂N₄O₅S 描述 概述 A cell-permeable 1,2,4-trisubstituted pyrrolidine derivative that acts as a highly specific and potent inhibitor of cPLA2α (cytosolic phospholipase A2α) (IC50 = 1.8 nM). Blocks the release of eicosanoids from A23187-stimulated THP-1 cells (IC50 = 22 nM for arachidonic acid, 31 nM for prostaglandin E2, 13 nM for leukotriene C4). Displays over 230-fold greater potency in the enzyme assay and ~ 3900-fold greater potency in the cellular assay than AACOCF3 (Cat. No. 100109). Does not exert any significant effects on the activities of cycloxygenase and 5-lipoxygenase. 产品目录编号 525143 品牌系列 Calbiochem®
同义词 N-{(2S,4R)-4-(Biphenyl-2-ylmethyl-isobutyl-amino)-1-[2-(2,4-difluorobenzoyl)-benzoyl]-pyrrolidin-2-ylmethyl}-3-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-phenyl]acrylamide, HCl, cPLA2α Inhibitor 参考 参考 Seno, K., et al. 2000. J. Med. Chem. 43, 1041. 产品信息 具有ATP竞争性 N 形式 Off-white solid Hill配方 C₄₉H₄₄F₂N₄O₅S 化学配方 C₄₉H₄₄F₂N₄O₅S Molar Mass 840.0 吸湿 Hygroscopic
可逆 N 结构配方图像 生物信息 主靶 cPLA2α 主靶IC50 1.8 nM against cPLA2α (cytosolic phospholipase A2α 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 75% Aqueous Acetic Acid or DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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