• merck millipore,默克密理博,524618,PIP3 Antagonist, PITenin-7 - Calbiochem
  • merck millipore,默克密理博,524618,PIP3 Antagonist, PITenin-7 - Calbiochem

    产品名称:PIP3 Antagonist, PITenin-7 - Calbiochem
    产品型号:524618
    The PIP3 Antagonist, PITenin-7 controls the biological activity of PIP3.

    merck millipore,默克密理博,524618,PIP3 Antagonist, PITenin-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,524618,PIP3 Antagonist, PITenin-7 - Calbiochem

    重要规格表

    经验配方
    C₂₂H₂₀N₂O₂S
    描述
    概述 A cell-permeable DM-PIT-1 (Cat. No. 524619) analog that is more selective and potent than DM-PIT-1 against PH domain-mediated PIP3 (Cat. No. 524615) binding to Akt1 (IC50 = 13.4 and 27.1 µM, respectively) and PDK1 (IC50 = 52.3 and 80.5 µM, respectively), while being much less active than DM-PIT-1 against PIP3 GRP1 PH domain binding (12% vs 84% inhibition with 100 µM respective compound). PIT-7 is also shown to be more effective than DM-PIT-1 in inhibiting human glioblastoma U87MG survival (IC50 = 6.6 vs. 33.9 µM, respectively) and cellular Akt Ser473 phosphorylation in cultures in vitro.
    产品目录编号 524618
    品牌系列 Calbiochem®
    同义词 N-(4-Hydroxybiphenyl-3-ylcarbamothioyl)-3,5-dimethylbenzamide, Phosphatidylinositol-3,4,5-triphosphate Antagonist, PITenin-7, PIT-7, Akt Inhibitor XX, PDK1 Inhibitor V
    参考
    参考 Miao, B., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 20126.
    产品信息
    形式 Yellow-white semi-solid
    Hill配方 C₂₂H₂₀N₂O₂S
    化学配方 C₂₂H₂₀N₂O₂S
    Molar Mass 376.5
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

    merck millipore,默克密理博,524618,PIP3 Antagonist, PITenin-7 - Calbiochem

上一件merck millipore产品:merck millipore,默克密理博,ZTSCXS008,ZipTip 微量层析柱,具有 0.6 µL 强阳离子交换树脂
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