merck millipore,默克密理愽
  • merck millipore,默克密理博,07-294,Anti-phospho-GluR2 (Ser880) Antibody

  • merck millipore,默克密理博,07-294,Anti-phospho-GluR2 (Ser880) Antibody

    产品名称：Anti-phospho-GluR2 (Ser880) Antibody
    产品型号：07-294
    This Anti-phospho-GluR2 (Ser880) Antibody is validated for use in IC, EA, WB for the detection of phospho-GluR2 (Ser880).

    merck millipore,默克密理博,07-294,Anti-phospho-GluR2 (Ser880) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-294,Anti-phospho-GluR2 (Ser880) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWB, ICCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-294
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-GluR2 (Ser880) Antibody
    产品信息
    格式 Affinity Purified
    控制
    • Brain tissue
    演示 Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
    应用
    应用 This Anti-phospho-GluR2 (Ser880) Antibody is validated for use in IC, EA, WB for the detection of phospho-GluR2 (Ser880).
    主要应用
    • Western Blotting
    • Immunocytochemistry
    生物信息
    免疫原品种 Thyroglobulin-conjugated, synthetic peptide (LVYGIE(PS)VKIA) corresponding to amino acids 873-883 of rat GluR2, with a phosphorylated serine at position 880
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes GluR2 phosphorylated on Serine 880.
    同种型 IgG
    品种反应性 Rat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000826
    Entrez基因汇总 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
    基因符号
    • GluR-K2
    • GRIA2
    • GluR-B
    • GLURB
    • gluR-B
    • GLUR2
    • GluR-2
    • HBGR2
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P42262
    UniProt汇总 FUNCTION: SwissProt: P42262 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
    SIZE: 883 amino acids; 98821 Da
    SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with PRKCABP, GRIP1 and GRIP2 (By similarity).
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
    SIMILARITY: SwissProt: P42262 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
    MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on HEK293T cells expressing GluR2, no detection in HEK293T cells expressing GluR2 S880A mutant
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-294,Anti-phospho-GluR2 (Ser880) Antibody

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