merck millipore,默克密理愽
  • merck millipore,默克密理博,559396,SB 220025

  • merck millipore,默克密理博,559396,SB 220025

    产品名称：SB 220025
    产品型号：559396
    A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC₅₀ = 60 nM).

    merck millipore,默克密理博,559396,SB 220025

  • 产品介绍

  • 重要规格表

    经验配方 CAS号
    C₁₈H₁₉FN₆165806-53-1
    描述
    概述 A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits over 2000-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1000-fold over EGFR. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.

    Please note that the molecular weight for this compound is batch-specific due to variable water content.
    产品目录编号 559396
    品牌系列 Calbiochem®
    同义词 5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV
    参考
    参考 Jackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
    Wang, Z., et al. 1998. Structure 6, 1117.
    产品信息
    CAS号 165806-53-1
    形式 White to pale yellow solid
    Hill配方 C₁₈H₁₉FN₆
    化学配方 C₁₈H₁₉FN₆
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    主靶 P38MAPK
    主靶IC50 60 nM
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas


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