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品种反应性 主要应用 宿主 格式 抗体类型 R, M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB15812 描述 Anti-Neuregulin-2 Antibody Alternate Names - neural- and thymus-derived activator for ErbB kinases
- neuregulin 2
- pro-neuregulin-2, membrane-bound isoform
- divergent of neuregulin-1
背景信息 Neuregulin-2 is a member of the neuregulin (NRG) family of epidermal-growth-factor (EGF) like growth factors. Neuregulin-2 binds directly to ErbB3 and ErbB4. It is thought to activate acetylcholine receptor (AChR) transcription and in neurons has been shown to accumulate at the synaptic locale. 产品信息 格式 Affinity Purified 控制 - Mouse brain tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Neuregulin-2 Antibody detects level of Neuregulin-2 & has been published & validated for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: 1:600 dilution from a previous lot detected Neuregulin-2 in normal human skin tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of mouse Neuregulin-2. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Neuregulin-2 at the C-terminus. 品种反应性 RatMouseHuman Species Reactivity Note Demonstrated to react with human, mouse, and rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001161363
基因符号 - pro-NRG2
- NTAK
- HRG2
- NRG2
- Don-1
- DON1
纯化方法 Affinity purified UniProt编号 - P56974
UniProt汇总 FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
SUBCELLULAR LOCATION: Pro-neuregulin-2, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein (By similarity). Note: Does not seem to be active (By similarity).
Neuregulin-2: Secreted (By similarity).
TISSUE SPECIFICTY: Highest expression in the brain, with lower levels in the lung. In the cerebellum, found in granule and Purkinje cells.
DOMAIN: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity).
PTM: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form (By similarity).
Extensive glycosylation precedes the proteolytic cleavage (By similarity).
SEQUENCE SIMILARITIES: Belongs to the neuregulin family.
Contains 1 EGF-like domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.产品使用声明 质量保证 Evaluated by Western Blot in mouse brain tissue lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected Neuregulin-2 on 10 µg of mouse brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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