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merck millipore,默克密理博,500580,Ezh2 Inhibitor III, GSK126
产品名称：Ezh2 Inhibitor III, GSK126
产品型号：500580
A cell-permeable structural analog of E1 that acts as an equipotent, SAM-competitive inhibitor of Ezh2/PRC2 inhibitor (Ki = 0.5 to 3 nM against wt & mutant Ezh2-containing PRC2).
merck millipore,默克密理博,500580,Ezh2 Inhibitor III, GSK126
- 产品介绍
重要规格表
经验配方 C₃₁H₃₈N₆O₂ 描述 概述 A cell-permeable EI1 (Cat. No. 500561) structural analog that acts as an equally potent, SAM-competitive, Ezh2/PRC2 inhibitor (Ki = 0.5 to 3 nM against wt & mutant Ezh2-containing PRC2; [SAM] = 7.5 µM) with similar selectivity over Ezh1/PRC2 (Ki = 89 nM) and other HTMases as EI1. Among panels of 14 HDACs, 11 GPCRs, and 300 kinases, only serotonin 3 receptor, JMJD2d, and CaMK1a are significantly inhibited at much higher concentrations (IC50 ≥4 µM). Shown to inhibit the proliferation of DLBCL (IC50 28 nM to 5.5 µM; 6 d treatment) in vitro and completely suppress Pfeiffer (A677G) and Karpas-422 (Y641N) tumor expansion in mice in vivo (50 mg/kg/d i.p.). 产品目录编号 500580 品牌系列 Calbiochem®
同义词 (S)-1-(sec-Butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide, Enhancer of Zested Homolog 2 Inhibitor III, HMTase Inhibitor XIV 参考 参考 McCabe, M.T., et al. 2012. Nature. 492, 108. 产品信息 形式 Brown semi-solid Hill配方 C₃₁H₃₈N₆O₂ 化学配方 C₃₁H₃₈N₆O₂ 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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