merck millipore,默克密理愽
  • merck millipore,默克密理博,500556,Tankyrase1/2 Inhibitor V, WIKI4 - Calbiochem

  • merck millipore,默克密理博,500556,Tankyrase1/2 Inhibitor V, WIKI4 - Calbiochem

    产品名称：Tankyrase1/2 Inhibitor V, WIKI4 - Calbiochem
    产品型号：500556


    merck millipore,默克密理博,500556,Tankyrase1/2 Inhibitor V, WIKI4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,500556,Tankyrase1/2 Inhibitor V, WIKI4 - Calbiochem

    重要规格表

    经验配方
    C₂₉H₂₃N₅O₃S
    描述
    概述 A cell-permeable triazole derivative that acts as a reversible TNKS inhibitor (IC50 = 15 nM) and selectively inhibits Wnt/β-catenin, but not NF-κB, TGFβ, or retinoic acid, signaling pathway-dependent transcription activity. Both WIKI4 and XAV939 (Cat. No. 575545) are shown to induce basal axin1/2 protein accumulation in DLD1 colon cancer cells (2.5 µM; 2 to 4 h) and prevent Wnt3a-induced axin1 protein degradation and β-catenin accumulation in A375 melanoma cells (1 µM; up to 24 h) with similar potency. Likewise, WIKI4 also effectively inhibits the Wnt/β-catenin pathway-dependent growth of DLD1 (by 67% in 10 days;1 µM).
    产品目录编号 500556
    品牌系列 Calbiochem®
    同义词 2-(3-((4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)sulfanyl)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione, Wnt Pathway Inhibitor XVIII, TNKS1/2 Inhibitor V
    参考
    参考 James, R.G., et al. 2012. PLoS. One.7, e50457.
    产品信息
    形式 Pale yellow powder
    Hill配方 C₂₉H₂₃N₅O₃S
    化学配方 C₂₉H₂₃N₅O₃S
    Molar Mass 521.59
    可逆 Y
    结构配方图像
    生物信息
    主靶 TNKS2
    主靶IC50 15 nM
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Followig reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,500556,Tankyrase1/2 Inhibitor V, WIKI4 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,07-787,Anti-phospho-Abl (Tyr245) Antibody


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