merck millipore,默克密理愽
  • merck millipore,默克密理博,324683,Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem

  • merck millipore,默克密理博,324683,Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem

    产品名称：Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem
    产品型号：324683
    A cell-permeable, reversible, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties.

    merck millipore,默克密理博,324683,Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,324683,Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₄H₆O₈ · 2H₂O476-66-4
    描述
    概述 A cell-permeable, reversible, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC50 = 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC50 = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC50 >40 µM). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation.
    产品目录编号 324683
    品牌系列 Calbiochem®
    同义词 4,4ʹ,5,5ʹ,6,6ʹ-Hexahydroxydiphenic Acid 2,6,2ʹ,6ʹ-Dilactone, TBBD, PRMT Inhibitor II
    参考
    参考 Selvi, B.R., et al. 2009, J. Biol. Chem. In press.
    Cozza, G., et al. 2006. J. Med. Chem. 49, 2363.
    Wang, B.H., et al. 1998. Planta Med. 64, 195.
    Constantinou, A., et al. 1995. Nutr. Cancer 23, 121.
    Hickey, M.J., et al. 1995. Biochem. Soc. Trans. 23, 607s.
    产品信息
    CAS号 476-66-4
    具有ATP竞争性 Y
    形式 Slightly Beige Powder
    Hill配方 C₁₄H₆O₈ · 2H₂O
    化学配方 C₁₄H₆O₈ · 2H₂O
    Molar Mass 338.2
    可逆 Y
    结构配方图像
    生物信息
    主靶 CDK2
    主靶IC50 40 nM against CK2; 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, against DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR, respectively
    纯度 ≥98% by HPCE
    理化信息
    细胞可渗透 Y
    溶解度 1 M NaOH or EtOH
    GHS安全信息
    RTECS DJ2620000
    安全信息
    R相 R: 36/37/38

    Irritating to eyes, respiratory system and skin.
    S相 S: 26-36

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +15°C to +30°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 week at -20°C. Alkaline solutions are unstable and should be prepared just prior to use.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,324683,Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem

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