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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB, ELISA Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-787 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-Abl (Tyr245) Antibody Alternate Names - ABL1, JTK7, c-ABL, p150, v-abl
- ABL1
- JTK7
- c-ABL
- p150
产品信息 格式 Affinity Purified 应用 应用 Anti-phospho-Abl (Tyr245) Antibody is an antibody against phospho-Abl (Tyr245) for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
生物信息 免疫原品种 KLH-conjugated peptide corresponding to amino acid region encompassing human c-Abl Tyr245. 宿主 Rabbit 特异性 Recognizes both Abl and BCR-Abl when phosphorylated on tyrosine residue corresponding to Tyr245 in Abl. 同种型 IgG 品种反应性 RatHumanMouse Species Reactivity Note Other species have not been tested. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_007313.2
- NM_005157.3
Entrez基因汇总 The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. 基因符号 - ABL
- ABL1
- JTK7
- p150
- bcr/abl
- v-abl
- c-ABL
修改 - Phosphorylation
纯化方法 Immunoaffinity purified UniProt编号 - P00519
UniProt汇总 FUNCTION: SwissProt: P00519 # Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.
COFACTOR: Magnesium or manganese.
SIZE: 1130 amino acids; 122873 Da
SUBUNIT: Interacts with SORBS1 following insulin stimulation. Found in a trimolecular complex containing CDK5 and CABLES1. Interacts with CABLES1 and PSTPIP1. Interacts with ZDHHC16 (By similarity). Interacts with INPPL1/SHIP2.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The myristoylated c-ABL protein is reported to be nuclear.
TISSUE SPECIFICITY: Widely expressed.
PTM: Phosphorylated by PRKDC (By similarity). DNA damage-induced activation of c-Abl requires the function of ATM and Ser-446 phosphorylation. Isoform IB is myristoylated on Gly-2.
DISEASE: SwissProt: P00519 # A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia (CML) [MIM:608232]. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
SIMILARITY: SwissProt: P00519 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
包装信息 数量 100 µL
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