merck millipore,默克密理博,495604,Okadaic Acid, Prorocentrum sp. - CAS 78111-17-8

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merck millipore,默克密理博,495604,Okadaic Acid, Prorocentrum sp. - CAS 78111-17-8 - Calbiochem
产品名称：Okadaic Acid, Prorocentrum sp. - CAS 78111-17-8 - Calbiochem
产品型号：495604
An ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties.

merck millipore,默克密理博,495604,Okadaic Acid, Prorocentrum sp. - CAS 78111-17-8 - Calbiochem

产品介绍

merck millipore,默克密理博,495604,Okadaic Acid, Prorocentrum sp. - CAS 78111-17-8 - Calbiochem

重要规格表

经验配方	CAS号
C₄₄H₆₈O₁₃	78111-17-8

描述
概述	An ionophore-like polyether derivative of a C₃₈ fatty acid compound that has tumor promoting properties. Potent inhibitor of protein phosphatase 1 (IC₅₀ = 10-15 nM) and protein phosphatase 2A (IC₅₀ = 0.1 nM). Does not affect the activity of tyrosine phosphatases, alkaline phosphatases, or acid phosphatases. Useful for the study of protein phosphatases in cell extracts as well as in intact cells. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF7) and in myeloid cells but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Has marked contractile effects on smooth muscle and heart muscle. Implicated as causative agent of diarrhetic shellfish poisoning. A 250 µM (25 µg/124 µl) solution of Okadaic Acid, (Cat. No. 495609) in DMSO is also available.
产品目录编号	495604
品牌系列	Calbiochem®
同义词	OA

参考
参考	Gjertsen, B.T., et al. 1994. J. Cell Sci. 107, 3363. Kiguchi, K., et al. 1994. Cell Growth Differentiation 5, 995. Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916. Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950. Kreienbuhl, P., et al. 1992. Blood 80, 2911. Nomura, M., et al. 1992. Biochemistry 31, 11915. Song, Q., et al. 1992. J. Cell Physiol. 153, 550. Tada, Y., et al. 1992. Immunopharmacol. 24, 17. Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98. Cohen, P. 1989. Annu. Rev. Biochem. 58, 453. Cohen, P., and Cohen, P.T. 1989. J. Biol. Chem. 264, 21435. Haystead, T.A., et al. 1989. Nature 337, 78.

参考

Gjertsen, B.T., et al. 1994. J. Cell Sci. 107, 3363.
Kiguchi, K., et al. 1994. Cell Growth Differentiation 5, 995.
Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
Kreienbuhl, P., et al. 1992. Blood 80, 2911.
Nomura, M., et al. 1992. Biochemistry 31, 11915.
Song, Q., et al. 1992. J. Cell Physiol. 153, 550.
Tada, Y., et al. 1992. Immunopharmacol. 24, 17.
Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
Cohen, P., and Cohen, P.T. 1989. J. Biol. Chem. 264, 21435.
Haystead, T.A., et al. 1989. Nature 337, 78.

产品信息
CAS号	78111-17-8
具有ATP竞争性	N
形式	Colorless glassy solid
Hill配方	C₄₄H₆₈O₁₃
化学配方	C₄₄H₆₈O₁₃
Molar Mass	805.0
可逆	N
结构配方图像

生物信息
主靶	Protein phosphatase
主靶IC₅₀	10-15 nM and 0.1 nM against protein phosphatase 1 and protein phosphatase 2A, respectively
纯度	≥95% by HPLC

理化信息
细胞可渗透	N
溶解度	MeOH, EtOH, DMF, CHCl₃

GHS安全信息
RTECS	AA8227800

安全信息
R相	R: 23/24/25-38 Toxic by inhalation, in contact with skin and if swallowed. Irritating to skin.
S相	S: 22-26-36/37/39-45 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Toxic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.