merck millipore,默克密理愽
  • merck millipore,默克密理博,492041,Nrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem

  • merck millipore,默克密理博,492041,Nrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem

    产品名称：Nrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem
    产品型号：492041
    The Nrf2 Activator II, AI-1, also referenced under CAS 75483-04-4, modulates the biological activity of Nrf2. This small molecule/inhibitor is primarily used for Biochemicals applications.

    merck millipore,默克密理博,492041,Nrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,492041,Nrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C13H₁₂ClNO₃75483-04-4
    描述
    概述 A cell-permeable chloro-quinolinone compound that selectively and covalently modifies Kelch-like ECH-associated protein 1 (Keap1)-Cys151 and represses Keap1 function and reduces Nrf2 (Nuclear factor erythroid 2-related factor 2)-Keap1 interaction. Shown to stabilize Nrf2 by inhibiting the Keap1-driven ubiquitination of Nrf2 and thereby activating the Nrf2-ARE (antioxidant response element) pathway (EC50 = 2.7 µM in neuroblastoma IMR-32 cells). Offers protection against H2O2 induced oxidative stress, but unlike tert-butylhydroquinone (Cat. No. 286888). AI-1 does not act as a free radical scavenger. Its anti-oxidant effects are mediated via Nrf2 induced antioxidant response. Does not affect mutant ARE where GC are substituted with AT within the core ARE sequence.
    产品目录编号 492041
    品牌系列 Calbiochem®
    同义词 Ethyl-4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate
    参考
    参考 Hur, W., et al. 2010. Chem. Biol. 17, 537.
    产品信息
    CAS号 75483-04-4
    形式 Off-white solid
    Hill配方 C13H₁₂ClNO₃
    Molar Mass 265.7
    可逆 N
    结构配方图像
    生物信息
    主靶 Keap1
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    防潮 Protect from moisture
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,492041,Nrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem

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