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品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB15157 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Ghrelin Antibody, active & proform 产品信息 格式 Serum 演示 Liquid. 应用 应用 This Anti-Ghrelin Antibody, active & proform is validated for use in WB for the detection of Ghrelin. 主要应用 - Western Blotting
应用说明 Western blot: 1:5,000-1:10,000 on extracts from mouse stomach.
Optimal working dilutions must be determined by the end user.生物信息 宿主 Rabbit 特异性 Ghrelin, active & proform. By Western blot the antibody recognizes a band at ~13 kDa using mouse stomach lysate. The band is completed abolished after incubating the antibody with the immunogen peptide. 品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_016362.2
Entrez基因汇总 Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor (GHSR; MIM 601898) and is involved in regulating growth hormone (GH; MIM 139250) release. Ghrelin is derived from a preprohormone called preproghrelin, which also generates a second peptide called obestatin. Obestatin is an endogenous ligand for the orphan G protein-coupled receptor GPR39 (MIM 602886) and is involved in satiety and decreased food intake.[supplied by OMIM] 基因符号 - GHRL
- ghrelin
- obestatin
- MTLRP
纯化方法 Serum UniProt编号 - Q9UBU3
UniProt汇总 FUNCTION: SwissProt: Q9UBU3 # Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
SIZE: 117 amino acids; 12911 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
PTM: O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28- C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28- C10:1, may be modified with a singly unsaturated carboxylic acid. & Amidation of Leu-98 is essential for obestatin activity (By similarity).
SIMILARITY: SwissProt: Q9UBU3 ## Belongs to the motilin family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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